The song also surges to No. 11 on the Hot 100.
Thirteen years into its chart career, Panic! at the Disco continues its hot streak of topping tallies for the first time, as the Brendon Urie-led band earns its first No. 1 on Billboard's Hot Rock Songs chart with "High Hopes."
The second single from the group's sixth studio album, Pray for the Wicked, ascends 2-1 on the Nov. 10-dated list, which blends streaming, airplay and sales data.
"Hopes" is the top Airplay Gainer on Hot Rock Songs for a fifth week, up 26 percent to 71.3 million all-format audience impressions, according to Nielsen Music. It also drew 10.5 million U.S. streams (up 6 percent) and sold 20,000 downloads (up 1 percent) in the tracking week.
A week earlier, "Hopes" became Panic!'s first No. 1 on Rock Digital Song Sales, where it remains at the summit.
The band had hit a previous No. 3 peak on Hot Rock Songs, which began in 2009, with "Hallelujah" in May 2015.
Elsewhere on radio, "Hopes" concurrently bullets at its No. 2 high on the Alternative Songs airplay chart. Now a crossover hit, it's scaling the Adult Pop Songs (8-6) and Pop Songs (15-12) airplay rankings. The song blasts 21-11 on the all-genre streaming-, airplay- and sales-based Billboard Hot 100, where the band is seeking its first Hot 100 top 10 since its debut entry, "I Write Sins Not Tragedies," reached No. 7 in 2006.
In addition to completing its first trips to No. 1 on Hot Rock Songs and Rock Digital Song Sales with "Hopes," Panic! notched its first Billboard airplay chart leader in June with lead Wicked single "Say Amen (Saturday Night)."
The band first reached a Billboard chart on Oct. 15, 2005, when its debut album A Fever You Can't Sweat Out arrived on multiple surveys, including at No. 1 on Heatseekers Albums.