It's the band's fifth leader on the list and first since 2015.
"Hunger" reaches the top of the chart in its sixth week, marking the second-quickest ascent to No. 1 in 2018. Nathaniel Rateliff & the Night Sweats' "You Worry Me" took just four weeks.
With its fifth No. 1, Florence + the Machine, fronted by Florence Welch, boast the second-most Adult Alternative Songs chart-toppers by a woman or a woman-led act in the chart's 22-year history, passing Norah Jones' four. Only Sheryl Crow, with seven No. 1s, has more.
Most Adult Alternative Songs No. 1s By Solo Women or Female-Fronted Acts
7, Sheryl Crow
5, Florence + the Machine
4, Norah Jones
3, Of Monsters and Men (vocals shared between female Nanna Bryndís Hilmarsdóttir and male Ragnar Þórhallsson)
Florence + the Machine had last led when "Ship to Wreck" ruled for three weeks in October 2015.
"Hunger" concurrently holds at its No. 12 peak on Alternative Songs and becomes the band's fifth top 10 on the all-rock-format Rock Airplay chart, lifting 12-10 with 5.9 million audience impressions, according to Nielsen Music.
The song is the lead single from High as Hope, Florence + the Machine's fourth studio album, due June 29.