After a stint in the Erskine Hawkins Orchestra, Reese signed a contract with Jubilee Records and released the top 20 hit "And That Reminds Me" in 1957, as well as six albums of mostly jazz standards. Her career took off after signing with RCA Records thanks to the track that would become her signature, 1959's "Don't You Know" -- adapted from Puccini's music for the opera La Bohéme -- which went all the way to No. 2 on the Billboard Hot 100 and No. 1 on R&B Songs, and scored her a Grammy nomination.
A series of successful albums followed, including 1962's The Classic Della and the next year's Waltz With Me, Della, which led to a nearly decade-long stint touring and performing in Vegas showrooms and two more Grammy nominations for a pair of gospel albums released in the 1990s.
By the late 1960s Reese switched careers and began pursuing acting, including a talk/variety show called Della -- the first of its kind to be hosted by a black woman -- which ran for nearly 200 episodes before its cancellation in March 1970. After becoming the first black woman to guest host The Tonight Show, Reese branched out into both sitcom and drama work, including recurring role on Chico and the Man, and guest spots in dozens of shows such as The Mod Squad, Police Woman, McCloud, 227, Night Court, Designing Women, Charlie & Co. and The Royal Family.
Her most iconic acting role came in 1994, when she took the lead as the "supervising angel" in the CBS TV drama Touched by an Angel, playing one of three heavenly spirits who try to help the living persevere through tough times. Reese earned two Emmy nominations, as well as Golden Globe and Screen Actors Guild noms during the series' nine-season run, which ended in 2003.
After the show's cancellation Reese continued to appear sporadically in TV series such as That's So Raven and The Young and the Restless, even as she served as a senior minister and founder of her church, Understanding Principles for Better Living in Los Angeles.
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