The producer and DJ continued, turning attention directly to her new album, Rebel Heart, on which he produced a number of tracks, including the new single, "Bitch I'm Madonna."
"Her song 'Ghosttown' was a guaranteed Number One for anybody else, but she didn't get a fair shot," he said. "With 'Bitch I'm Madonna,' everyone said there's no way it will go anywhere, but I'm like, 'Screw it, it represents you more than anything.'"
Diplo also touched on his relationships with Justin Bieber and Taylor Swift.
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About the Bieber-featuring "Where R U Now," from his Jack Ü collaboration with Skrillex, he said the singer had been "stuck in a rut where he has to do a certain thing because of his fan base.... Bieber's personal life is whatever it is — he's a rich kid and he's pretty much gonna have to be a jerk. But he's respectful to me, and he has that weird gene where he's good at everything: better at basketball than me, better at drums. For us it's more like an art project where you utilize his voice."
And he added that the beef with Swift has been officially squashed, following his comments about her "booty" last year.
"I saw her at the Grammys and she was super nice and cool," he said. "Her fans loved the beef, though. That's all they have — they don't have, like, real things going on. It's still startling when these artists pay attention to my Twitter. Like, Ed Sheeran unfollowed me when I said something about Taylor — I can't believe these people even know who I am."
Read the full interview here.