"Who would have thought that more than 25 years after its inception, thrash metal's Big Four would not only still be around, be more popular than ever, playing shows together at stadiums all over Europe, and on top of that, coming to a movie theater near you in High Definition (for better or worse)," said Metallica's Lars Ulrich in a statement.
Megadeth's Dave Mustaine added: "The magnitude of this event hasn't really sunk in yet, and I am thrilled to know that people around the planet will be able to walk into a movie theater and experience the greatest line up of Heavy Metal in the history of the world."
The screening will run for four hours from 6.30pm GMT and 79 U.K. cinemas will be feature the event. More than 30 Cineworld sites are among the cinemas offering tickets.
"It offers something a little different that many wouldn't expect to see at the cinema," said Cineworld head of marketing communications Luke Roberts in a statement.
"The Big Four: Metallica, Slayer, Megadeth, Anthrax" digital cinema event is distributed globally by New York-based BY Experience.
Details of participating theater box offices are at www.thebigfourlive.com, where fans can also view the event cinema trailer.