The tweet storm appeared to kick off with a single post, without comment, of Michael Jackson's music video to "Black or White."
From that point forward, Kanye fired away. With family members among the targets, including wife Kim Kardashian West and mother-in-law Kris Jenner.
"I put my life on my God that Norths mom would never photograph her doing playboy and that’s on God I’m at the ranch ... come and get me," he wrote.
In another, "I love my wife My family must live next to me It’s not up to E or NBC anymore."
Without explanation, Kanye tweeted "NBC locked up Bill Cosby." As a result, the disgraced, imprisoned comedian's name began trending on Twitter.
In another, Ye referenced the Oscar-winning thriller Get Out when he claimed his wife had a doctor ready and en route to Wyoming to "lock me up."
"Kim was trying to fly to Wyoming with a doctor to lock me up like on the movie Get Out because I cried about saving my daughters life yesterday," he tweeted.
He continued, "Everybody knows the movie get out is about me."
There are no positive connections to find between being locked up and Jordan Peele's Get Out, a film in which (spoiler alert) some quietly creepy mental health practitioners use dark methods on their guests.
Several messages have since been deleted, and more had been pulled at press time. The "Pray for Ye" hashtag was trending late in the evening as fans and onlookers piled on with shock and concern for his health.
In the small hours, Kanye appeared to tire and changed directions. "Ima focus on the music now," he wrote, at which stage most of his earlier tweets had been scrubbed.
And then, an announcement: "DONDA coming this Friday," a seeming reference to his previously announced upcoming album.
Kanye's troubling Twitter frenzy came on the heels of multiple published reports claiming that he failed to file the required paperwork to have his name appear on South Carolina's presidential ballot.