The actress is married to Franco's brother, Dave.
E!'s red-carpet preshow for the SAG Awards had barely begun when host Giuliana Rancic put nominee Alison Brie on the spot with a question about the sexual misconduct claims against brother-in-law James Franco.
Franco, who's nominated for best actor for his role in The Disaster Artist, has been accused of sexually inappropriate or exploitative behavior by at least five women, with a number of people taking to Twitter after Franco won his best actor Golden Globe to accuse him of inappropriate behavior.
Brie is married to Franco's brother, Dave, who also appears in The Disaster Artist.