"This song is for the oppressed. That's why I feel like people will connect with it because it is very broad, because oppression is so broad," he said in an interview Tuesday with The Associated Press.
"That mask is a representation of this false idea of patriotism. And that mask is a representation of this idea of white male privilege," 34-year-old Smollett said. "It's so much bigger than him. It's what he represents, and it's because of that representation, that's why he's the president of the United States currently."
"It's our opportunity to take those masks off and shatter them, so that's what I did," he added.
Trump's apparent mocking of a disabled reporter was widely criticized last year. Some of Smollett's "F.U.W." lyrics focus on Trump and his administration: "Why are we back in the past?/It's the same script different cast/All of these alternative facts/Catch me outside how about that?/Why is it so hard to keep hope?/Who got that popular vote?/Was the whole thing just a joke?/Was the whole thing just one big joke?"
On Wednesday, Trump fired back at rapper Snoop Dogg days after the release of a music video in which he points a toy gun at a clown dressed like Trump and pulls the trigger.
Trump tweeted: "Can you imagine what the outcry would be if @SnoopDogg, failing career and all, had aimed and fired the gun at President Obama? Jail time!"
The White House did not immediate return a request seeking comment about Smollett's video, which also features a black man standing in front of a noose, images of barbed wire and two water fountains with "white" and "colored" signs above them.
"We had written so many other great songs for my album, but this just felt like 'I can't wait for the album, I can't wait for a single,'" said Smollett, who plans to release an official single this summer. "You couldn't follow, you know, normal rules or normal protocol with this, you just had to get it out and luckily Columbia (Records) stood behind me."
During the presidential campaign, Smollett and other Empire cast members appeared in an ad endorsing Democratic nominee Hillary Clinton.
Smollett, who was one of the kid stars of The Mighty Ducks film, is set to appear in Ridley Scott's science fiction film Alien: Covenant this year. He said it was "freeing" to release a song apart from his Empire persona, and he challenged himself by directing the video.
"Because the song means so much to me and the message means so much to me, and what we're going through right now means so much to me, I wanted to do it justice. And I knew what was in my mind would do it justice," he said.