Isgro declined to comment as he left court, but his lawyer, Aaron M. Rubin, said his client "strenuously denies the charges."
The case begins a new chapter in the tale of a Hollywood figure whose own story sounds like the makings of a movie. Indeed, it was a screenplay-in-the-making as recently as last year, according to a press release from the intended writer.
The planned title: Hit Man.
Isgro, 66, has been a music-business player for decades, coming to prominence when independent promoters exerted enormous influence over what songs Americans heard on Top 40 radio. As a leading promoter, Isgro ran a company that grossed as much as $10 million a year during the 1980s.
He came under scrutiny after a 1986 NBC News story examined what it called the resurgence of payola -- bribing radio station employees to play certain records, a practice that spurred congressional hearings and legislation in the 1960s. The TV report suggested promoters were winning airplay with cash and cocaine and raised the specter of Mafia involvement.
Labels rapidly jettisoned independent promoters, at least temporarily, and federal authorities began probing record-promotion practices. Indicted in 1989, Isgro denied doing anything illegal.
Some associates pleaded guilty, but he went to trial in Los Angeles in what was seen as the biggest payola case in decades. It collapsed when a judge threw out the case mid-trial in 1990, saying prosecutors had withheld key information from Isgro's lawyers and calling it "outrageous government misconduct."
Prosecutors tried unsuccessfully to revive the case for six more years -- before the lead prosecutor pleaded guilty himself to unrelated charges of taking more than $133,000 from informants and felons.
Meanwhile, Isgro pressed ahead with a record label he had founded, releasing albums by funk master Rick James and others. He also dived into the movie business, serving as executive producer of the 1992 biopic Hoffa, starring Jack Nicholson.
In 2000, Isgro was arrested outside a Beverly Hills shopping center where prosecutors said he lent money at interest rates of up to 5 percent a week, browbeat borrowers who fell behind and ordered henchmen to just plain beat them. Isgro pleaded guilty to extortion and served about three years in prison.
Prosecutors in that case said he was a soldier in the Gambino crime family, an assertion echoed in the new gambling indictment brought by Manhattan District Attorney Cyrus R. Vance Jr. It describes Isgro talking with a now-dead reputed mob bookie about sports betting payments and software in 2009.
Since his release from federal prison, Isgro has continued making music distribution deals. And he has said his alleged Gambino ties are bunk.
"I'm a soldier, all right -- a decorated veteran of the Vietnam War," the Purple Heart recipient told the Los Angeles Times in 2007. "And a proud member of the Isgro family."
Rubin, the defense lawyer, noted that the new allegations date back about five years.
"This looks to be an ancient case, an ancient investigation, and we're looking forward to having our day in court," Rubin said.