The superstar has grown from a young singer in Bay City, Michigan, to a globe-trotting icon over the course of her 54 years. Scores of hit songs and millions of albums sold later, the Queen of Pop is still going strong, supporting new album "MDNA" with one of her most ambitious world tours yet.
1. Huey Lewis & The News
The SF pop-rock giants are best known for their string of hits during the 80s, crafting indelible cuts like "Back in Time," "The Heart of Rock & Roll" and "The Power of Love," the latter of which was spotlighted in "Back To the Future." Lewis & The News are still going strong as well, with a new album currently in the works.
2. Stevie Wonder
The Motown legend became one of the most celebrated musical artists of the 20th century after growing up in Detroit. 1973's "Innervisions" and 1976's "Songs in the Key of Life" both won the Grammy Award for Album of the Year.
Well before "Rock of Ages," "The Sopranos" finale or even (gasp!) the "Glee" cover, Journey formed in San Francisco and spent years honing their now-signature epicness. With singer Steve Perry joining the group in 1977, the blueprint for their enduring hits -- "Don't Stop Believing," "Any Way You Want It," "Open Arms" -- was set.
3. Aretha Franklin
The Queen of Soul went from singing solos at her father's church in Detroit to spellbinding millions with hits like "Respect," "(You Make Me Feel Like) A Natural Woman" and "Chain of Fools." Popular music wouldn't be the same without Franklin, who turned 70 earlier this year.
Carlos Santana - the Mexican-born son of a mariachi musician, moved to San Francisco in 1962 and formed the Santana Blues Band, a group marked by its scorching Latin rock. From Woodstock to "Supernatural," the guitarist's presence has burned on in mainstream rock, after over a dozen albums and lineup changes.
4. Diana Ross
The Supremes leader has had a supreme effect on R&B and soul music, rising to superstardom after humble beginnings in Detroit. Ubiquitous hits include "Ain't No Mountain High Enough," "I'm Coming Out" and "Endless Love" with Lionel Richie.
4. The Steve Miller Band
Formed in San Francisco in the late 1960s, the Steve Miller Band have become reliable classic-rock staples with hits like "Abracadabra," "The Joker" and "Fly Like an Eagle." Miller, now 69, led the band in releasing its 17th studio set, "Let Your Hair Down," last year.
5. Bob Seger
The rock singer-songwriter has been crafting heartland anthems for decades, long before "Night Moves" or even the formation of the Silver Bullet Band. Seger continues to represent Detroit and sell out shows, eight years after his induction into the Rock and Roll Hall of Fame.
The most successful San Francisco group of the past decade has stayed in the public consciousness through the release of radio-ready singles like "Hey, Soul Sister," "Drops of Jupiter," "Meet Virginia" and most recently, "Drive By." "Hey, Soul Sister," off the 2009 album "Save Me, San Francisco" scored Train a Grammy for Best Pop Performance by a Duo or Group in 2011.
Call him Slim Shady, Marshall Mathers or simply Em -- whatever name you use for him, the hip-hop titan is as undeniable today as when he was participating in freestyle battles in Detroit. Following his early career success and subsequent drug addiction, Eminem returned triumphantly in 2010 with "Recovery," the best-selling album of that year.
6. Third Eye Blind
No band screams "90s alt-rock radio" quite like Third Eye Blind, a group that earned scores of fans through inescapable jams like "Semi-Charmed Life," "How's It Going To Be" and "Jumper." After a lengthy hiatus, Stephan Jenkins and co. returned in 2009 with the comeback effort "Ursa Major."
An R&B force whose story tragically ended too soon, Aaliyah remains an enduring icon after being raised in Detroit in the 1980s. Before her untimely death in 2001, Aaliyah teamed with white-hot producer Timbaland for timeless hit singles like "Are You That Somebody" and "Try Again."
7. Bonnie Raitt
Fans of Bon Iver and Mumford & Sons would be wise to revisit the magic of Bonnie Raitt, the California folk icon who became a star in the mid-70s. "Slipstream," the singer-songwriter's first album in seven years, was released in April.
8. Smokey Robinson
The North End native forged a staggeringly successful solo career following a famous stint as the leader of The Miracles. After releasing the solo album "Time Flies When You're Having Fun" in 2009, Robinson is currently working on a "Spanglish" album.
8. Tommy Tutone
Has telephone-themed power-pop ever received a better moment that "867-5309/Jenny," the hit single from Tommy Tutone? Although the group was never able to return to the chart heights of their 1981 single, Tommy Tutone still has 80s fans dialing up their music.
9. Alice Cooper
The hard rock staple is still head-banging at 64 years young after growing up in Detroit. A constant touring presence in the 2000s after securing his legacy in the 70s and 80s, Cooper and his band will be declaring that school's out… forever.
9. Chris Isaak
Best known for his seductive hit "Wicked Games," Isaak has spent nearly three decades releasing roots-rock albums and showing off his dazzling guitar work. The musician even received his own subversive TV show, "The Chris Isaak Show," which ran on Showtime from 2001-04.