The star-studded affair opened with a pre-dinner performance by Bono, who keyed in on the Sinatra phase of Jones' career with performances of "I Got You Under My Skin" and "Fly Me to the Moon."
The post-dinner concert, a journey through Jones' and Caine's storied lives, featured performances by Jennifer Hudson, Herbie Hancock, Carlos Santana, Snoop Lion, Jordin Sparks, Patti Austin with James Ingram, Stevie Wonder and Chaka Khan (who sang a mean version of "Alfie" in salute to Caine).
Also making appearances were Amy Poehler, Chris Tucker, Arsenio Hall, Whoopi Goldberg, Larry King and Jones' daughter Rashida Jones.
Announced as a performer in March, Barbra Streisand unfortunately did not appear.
After Wonder led the audience in singing "Happy Birthday" to Jones and Caine -- both born on March 14 -- the two men walked onstage to say thanks. "I'm so proud of this night being on behalf of charity," said Jones. "Living, laughing, loving and giving … that's what life is about." Added Caine, "Me and Q have been called legends, but the real legends are at the [Cleveland Clinic]." To wrap the evening, will.i.am led the evening's performers in "We Are the World."
The dinner itself, featuring roasted Beef Wellington as the main course, was helmed by noted chef Gordon Ramsay (who later paid tribute to fellow British mate Caine). A different wine accompanied each course.
Jones' next birthday celebration takes place July 21 at the Montreux Jazz Festival where he will be honored with his late friend and festival founder Claude Nobs. Three days later, Jones and Caine will party again at London's Royal Opera House. Then on July 31 and Aug. 1, Jones' final birthday bash will take place in Tokyo with Japanese music executive Tom Nagashima, son of the late concert promoter Tats Nagashima.