Jimmy Fallon, Kim Kardashian, Alicia Keys and Puff Daddy will also present awards, while attendees at Madison Square Garden will include Kanye West, Bryson Tiller, 2 Chainz, DNCE, Desiigner and Troye Sivan.
Britney Spears, Rihanna, Future, Ariana Grande, Nicki Minaj, Nick Jonas and the Chainsmokers will perform during the live show.
Beyonce is the leading nominee with 11, followed by Adele with eight nominations. Adele won't attend the show; a representative for Beyonce didn't immediately say if the singer would attend.
Beyonce, Adele, West, Justin Bieber and Drake will compete for video of the year.