The 15-episode hourlong comedy will premiere in fall 2015, with season one set on a college campus that's rocked by a series of murders. New settings and storylines will be featured in subsequent seasons of the anthology series. Production will begin in the spring.
Michele, Manganiello, Michele and Breslin will be series regulars, while Grande will guest star in a recurring role. Plot details are being kept under wraps. The casting comes as Michele is wrapping the sixth and final season of Glee and marks her first role after the Fox musical.
They join the previously announced Emma Roberts (American Horror Story) and horror icon Jamie Lee Curtis (True Lies). Roberts is set to star in the comedy, with a second young actress set to co-star (likely Breslin). A casting breakdown indicates the series will center on three young women, Curtis' role and a father.
The series hails from 20th Century Fox Television, where Murphy and Glee/American Horror Story co-creator Brad Falchuk are under rich overall deals. Glee's Murphy, Falchuk and Ian Brennan created Scream Queens and will exec produce alongside Dante Di Loreto.
Michele is repped by WME, Untitled and Sloane Offer; Manganiello (Magic Mike) is with CAA, Schlegal Entertainment and Myman Greenspan; Breslin (Zombieland) is with CAA, Envision Entertainment and Lichter Grossman. Palmer (Masters of Sex) is represented by WME, Anonymous Content and Goldring Hertz; Grande, who previously guest starred on Glee, is with CAA and Untitled.
This article originally appeared in THR.com.