Will Kanye West perform his brand-new song "Fade" for the first time?
The song just debuted Wednesday at the last-minute Yeezy Season 2 show at New York Fashion Week, so this will be West's first chance to perform the AutoTuned, Motown-sampling track.
Could Janet Jackson and her onetime dancer Jennifer Lopez hit the stage together?
OK, this is a total pipe dream, but bear with us: Both divas are on Friday's lineup, and Lopez once danced for Jackson, appearing in the video for "That's the Way Love Goes." A re-creation of this video might break the Internet.
Update: This will definitely not happen. Janet Jackson has pulled out of the festival.
What special guests might join Puff Daddy?
After his epic medley at June's BET Awards, is it too much to hope for a few Bad Boy all-stars to hit the stage with the many-named rapper and mogul? Let's do this thing, Lil' Kim!
Is there any chance Sam Smith will sing the new Bond theme "Writing's on the Wall"?
Now that we know the Brit is next in line for the prestigious 007 soundtrack spot, we would love to get even a taste of the Spectre theme song.
How many "never-before-imagined" collaborations can we imagine?
OK, here are our predictions, based on the iHeartRadio press release's promise of "never-before-imagined" collabs: We're going with Diplo and Blake Shelton on Friday, followed by a Duran Duran-meets-Demi Lovato acoustic set on Saturday. OR maybe it will be a Bond theme mash-up with Smith and Duran Duran? We can only hope.
Stick with Billboard.com and the Billboard social sites for our iHeartRadio coverage all weekend.