Raking 82 percent of the votes, the collab beat out other songs that hit No. 1 on Billboard's Hot Latin Songs chart in 2010 such as Aventura's "Dile Al Amor," Banda Los Recoditos "Ando Bien Pedo" and Chino Y Nacho's "Mi Niña Bonita."
"Cuando Me Enamoro" peaked at No. 1 on June 12, 2010 and ruled the tally for 17 weeks. On YouTube, the music video has nearly 700 million views.