The hip-hop duo kept it strictly to music during the majority of the program, but broke their silence toward the end and encouraged viewers to vote on Nov. 3.
"We believe the last thing that they want you to do is get out of your house and march down in person, mask on and cast your ballot for what you think this country is supposed to be, for what you think this country is supposed to reflect," El-P said during the closing track "A Few Words for the Firing Squad." "We want you to go down there. And when you get there, tell them Run the Jewels sent you."
Killer Mike, who was the first recipient of Billboard's Change Maker Award at the Billboard Music Awards on Oct. 14, added, "Vote local, vote down the ballot. Vote for your major, judges, prosecutors -- for the people looking over your life. Vote the b------s out of office and keep the good folks in."
Watch Run the Jewels' performance of RTJ4 in the video below.