The MC, 23, had reached the Hot 100 once before, with "My Dawg," which peaked at No. 71 in January.
Lil Baby (whose full name is Dominique Jones) adds his third and fourth entries on the Hot 100, as "Southside" debuts at No. 79 and "Life Goes On," featuring Gunna and Lil Uzi Vert, arrives just behind at No. 80. Both tracks, along with "Yes Indeed," are from Lil Baby’s debut studio album Harder Than Ever, which starts at No. 3 on the Billboard 200 with 71,000 equivalent album units.
"Life Goes On" earns fellow Georgia-based rapper Gunna, 24, his first entry on the Hot 100. He also debuts at No. 50 on the Emerging Artists chart.
"Yes Indeed" is also monumental for Drake, who passes Elvis Presley (26 to 25) in the race for the fourth-most Hot 100 top 10s among solo males. Madonna leads all acts with 38 top 10s, followed by The Beatles (34), Rihanna (31), Michael Jackson (29), Mariah Carey and Stevie Wonder (28 each) and Janet Jackson and Elton John (27 each).