The track debuts at No. 9 on the Digital Song Sales chart, earning Mendes his seventh top 10.
The single also sports 19 million radio audience impressions in the week ending March 25, sparking its No. 30 arrival on the Pop Songs airplay chart and No. 31 start on Adult Pop Songs.
"Blood" is likely to see a sizable jump on next week's Hot 100 (dated April 7), as that chart will encompass the song's first full week of tracking. (Streaming and sales run on a Friday through Thursday tracking cycle, while airplay runs Monday through Sunday.)
Next week's charts could also see action for fellow new Mendes song "Lost in Japan," released March 23.
Mendes has now earned nine total Hot 100 entries, dating to his first, the No. 24-peaking "Life of the Party," in 2014. His five entries prior to "Blood" have all reached the top 20, including his three career top 10s so far: "Stiches" (No. 4, 2015), "Treat You Better" (No. 6, 2016) and "There's Nothing Holdin' Me Back" (No. 6, 2017).