The song, penned by Williams, Casey Beathard and Jonathan Smith, marks Parton's first No. 1 on Billboard's Christian charts.
"Having a No. 1 record at any time is a great thing, but having a No. 1 faith-based record during these crazy times is even greater," Parton tells Billboard. "I feel humbled and blessed to be part of this wonderful song with Zach Williams. It does my heart good to know that we have touched the lives of so many people."
For Williams, "Jesus" marks his third Christian Airplay leader. His first entry "Chain Breaker" reigned for 15 frames beginning in November 2016 and "Old Church Choir" dominated for 20 weeks starting in August 2017. All three titles have also led Christian AC Songs.
Parton, meanwhile, expands her domination atop Billboard's charts. Most notably, she has amassed 25 No. 1s on Hot Country Songs, the most among women; seven leaders on Top Country Albums; and two No. 1s on the all-genre Billboard Hot 100 songs chart.
On Country Airplay, which started in January 1990, Parton has notched two No. 1s. Her duet with Ricky Van Shelton, "Rockin' Years," led for a week in May 1991 and Brad Paisley's "When I Get Where I'm Going," featuring Parton, paced the list for one frame in March 2006.
On Adult Contemporary, she has scored two No. 1s with country crossover hits. "9 to 5" led for two weeks starting in February 1981 and "Islands in the Stream," with her oft-duet partner Kenny Rogers, ruled for four weeks beginning in October 1983.
Last December, Parton earned her first No. 1 on Billboard's Dance/Mix Show Airplay chart, as "Faith," with Galantis and featuring Mr. Probz, led for a week.
Thanks to her latest leader, Parton becomes the first artist to have topped the Adult Contemporary, Christian AC Songs, Christian Airplay, Country Airplay and Dance/Mix Show Airplay radio charts.
In her Billboard chart history, which dates to the January 1967 Hot Country Songs debut of her first hit, "Dumb Blonde," Parton has also led Americana/Folk Albums and Gospel Digital Song Sales.
"I don't even know hardly what to say about all the No. 1s in all the different fields of music," Parton marvels. "Thank you God, thank you fans and thank you everyone who has worked so hard to make this possible."