"I mean, that was part of the draw," Schumer said of taping at home without cameras filming. "There's just such a feeling of us hanging out like we would anyway."
The casual environment helped set the tone for the weekly podcast, which features Schumer and friends discussing love, relationships, sex, comedy, politics and more. Guests will appear each week; comedian Murray Hill and "Crazy-Ex Girlfriend" actress Rachel Bloom are featured on episode one and two.
Schumer said some of the podcasts she listens to includes "This American Life," "S-Town," Esther Perel's "Where Should We Begin" and "Oprah's SuperSoul Conversations." But part of the appeal of doing her own was because she's hadn't heard any podcast like the one she wanted to produce.
The idea of doing a podcast started as a joke, Schumer said, and she had been thinking about doing it for a year.
"The goals were to make us all some money and just to hang out, honestly," she said, adding that the podcast will let listeners "be a fly on the wall, just hearing casual conversation with friends and then also sometimes, maybe learn something or hear a perspective they didn't have before."
Schumer and friends also discuss their personal lives on "3 Girls, 1 Keith." She tied the knot in February and said she's enjoying married life.
"It's funny, before you're married, people don't really tell you, but then once you get married, you talk to other married couples and they're like, ‘Marriage is awesome!' And you're like, ‘Yes, it is,'" she said.
"It was like a secret, because they don't want to tell you because they don't want you to be jealous or something. But it's nice. I don't think it's totally necessary, but if you're into it, it's pretty dope."
Schumer has had major success on TV, in movies, on comedy tours in arenas where pop stars perform, and even Broadway, earning herself a Tony nomination this year. When asked what advice she has for young female comedians, she said: "I would actually not give any different advice to a female comic then I would to a male comic."
"Not for any reason other than the advice is really the same. It's because it's not harder for female comics, it's just harder for females ... (it's) even harder than that for people of color in terms of equality and just like stuff that they're going to encounter," she added.
"But for comedy, I would always just say to any performer, ‘There's nothing like just doing it.' As much stage time as possible. I wish there's some other thing, but that's really the truth — you just have to do it. You have to do it and do it so much that it has to be all that you care about until you don't care anymore."