It's not known what role the disease played in Hanneman's liver failure.
Throughout the ordeal, Hanneman's bandmates expressed optimism that he would one day return to the group full-time. Bassist-singer Tom Araya told Billboard during last year's Rockstar Energy Drink Mayhem Festival tour that Hanneman was "free of the disease" and was "working on his playing ability...He's working on strengthening his arm and his ability to play." He predicted that Slayer would "probably get together and start writing together and start making a new album," the group's first since 2009's "World Painted Blood," with Hanneman contributing material.
But in February guitarist Kerry King told Australian press that "we don't know when Jeff's gonna be able to play guitar. Jeff's kind of like a wait-and-see thing."
Born in Oakland, Calif., and a devoted Raiders fan, Hanneman was raised primarily in Long Beach and became fascinated with wars and military campaigns -- themes he'd bring to Slayer's music -- via his father, a World War II veteran, and brothers who served in Vietnam. He met King in 1981 and decided to form their own band, mixing heavy metal and punk influences and signing with Metal Blade Records for Slayer's first two albums, "Show No Mercy" in 1983 and "Hell Awaits" in 1985. The group made an eyebrow-raising move to the hip-hop label Def Jam in 1986 for the covers album "Undisputed Attitude and the classic "Reign in Blood."
Slayer has released seven more studio albums and two live albums, as well as a pair of EPs. They've sold 4.9 million albums in the SoundScan era (1991-present), with the classics "Reign in Blood" (1986), "South of Heaven" (1988) and "Seasons of the Abyss" (1990) accounting for over 2 million of that tally. Ten of their albums have charted on the Billboard 200, with 2006's "Christ Illusion" being the highest debut at No. 5.
Hanneman, an ardent collector of World War II memorabilia, was at the center of the controversy over Slayer's supposed Nazi sympathies, stemming from the resemblance of the group's eagle logo to a Third Reich image and the shape of the S in the group's typography, and from songs such as "Reign in Blood's" "Angel of Death," about German doctor Josef Mengele and his horrific "experiments" at the Auschwitz death camp. But Hanneman frequently explained that the song was in no way intended to glorify Mengele. "I know why people misrepresent it," he told one radio interviewer. "It's because they get a knee-jerk reaction to it. There's nothing I put in the lyrics that says necessarily he was a bad man because to me -- well, isn't it obvious? I shouldn't have to tell you that."
Hanneman's songs have been recorded by groups such as Hatebreed, Children of Bodom, Hellsongs, Cradle of Filth and others, and sampled by rapper Styles-P. He's survived by Kathy, his wife of 16 years, sister Kathy and two brothers, Michael and Larry. Funeral arrangements are pending.