"Lollipop"

Lil Wayne

Lil Wayne [1] backed up partner-in-crime T-Pain and stamped his co-sign on Auto-Tune by using the software in his Hot 100 No. 1 "Lollipop."

"Blow"

Ke$ha

Ke$ha [2] has heralded the pop return of obvious Auto-Tune in recent years, first with her debut single "TiK Tok" and most recently with "Blow," whose chorus would certainly falter from a lack of Auto-Tune.

"One More Time"

Daft Punk

Daft Punk's [3] 2000 single "One More Time" is certainly not the French DJ duo's only foray into Auto-Tune, but it might just be their best. The tuned and compressed vocals from DJ/producer Romanthony [4] seem an almost natural fit alongside heavy dance beats on the "Discovery" single.

"Boom Boom Pow"

The Black Eyed Peas

No surprise here, as will.i.am [5] will try (almost) anything once. The mega-successful pop group gave a nod to Auto-Tune with the Hot 100 No. 1 hit, "Boom Boom Pow."

"Sensual Seduction"

Snoop Dogg

"Sensual Seduction" (unedited as "Sexual Eruption") captures Snoop [6] in a retro '80s 'fit, singing into a talk box. A perfect celebration to Auto-Tune.