Newcomer Ke$ha takes her first solo chart single "TiK ToK" to the top of the Billboard Hot 100 (2-1), set to be released on Billboard.com Thursday (Dec. 24). Ke$ha is the first female vocalist to rise to No. 1 with her debut single since Lady Gaga stormed the list with "Just Dance" in January 2009.

"TiK ToK" is actually the second Hot 100 No. 1 to feature vocals by the 22-year-old. She had a non-credited appearance on Flo Rida's six-week chart-topper "Right Round" earlier this year. "TiK ToK" is the first single from Ke$ha's debut album, "Animal," which is set for a Jan. 5 release.

"TiK ToK" also moves 2-1 on Digital Songs with 221,000 downloads (up 40,000) and is the Digital Gainer on the Hot 100. The song's weekly total is the highest sum since Britney Spears' "3" posted 254,000 on the chart dated Oct. 24. "3" remains in the Hot 100 top 10, falling 9-10 this week.

Ke$ha's move to the top bumps "Empire State of Mind" by Jay-Z and Alicia Keys from its perch (1-2) after a five-week run. In a rare chart occurrence, an acoustic version of "Empire" by Keys debuts at No. 55. Most often, different takes of a song are merged with the original versions for the purpose of chart rankings, but in the instance where a contributing vocalist (Keys) takes the reigns without help from the lead act (Jay-Z), the songs are tracked separately.

It's another stationary week in the Hot 100 top 10, as no new tracks enter the upper tier for a third straight frame, the longest stretch in almost six years. Rihanna was close to ending the drought this week as "Hard," featuring Jeezy, hops 21-11.

Lady Gaga's "Bad Romance" holds at No. 3 and is the Airplay Gainer for a third straight week, gaining 15 million listener impressions (to 91 million) while jumping 6-3 on Radio Songs.

The songs at Nos. 4-7 all remain in place: Iyaz's "Replay," Owl City's "Fireflies," "Sexy Chick" by David Guetta Featuring Akon and Jason Derulo's "Whatcha Say," respectively.

Jay Sean's "Down" rebounds 10-8, while the Black Eyed Peas slip 8-9 with "Meet Me Halfway."

Eminem has the chart's Hot Shot Debut, coming in at No. 29 with "Hell Breaks Loose." The song features Dr. Dre and is one of the new tracks that appear on Eminem's re-released "Relapse: Refill." Another new cut, "Elevator," debuts at No. 67. "Hell" opens at No. 12 on Digital Songs (74,000 downloads) with "Elevator" entering at No. 31 on that sales tally with 36,000.

Rounding out the Hot 100's debuts are Adam Lambert's "Whataya Want From Me" (No. 72), Robin Thicke's "Sex Therapy" (No. 79) and "Hey Daddy (Daddy's Home)" from Usher featuring Plies (No. 94).