Monday's night performance was stopped short after an unidentified performer -- either the actor playing the title character or his stunt double -- fell about eight to 10 feet during the final moments of the show, the New York Times reported. Some equipment also fell into the audience when the fall happened.
"He fell several feet from a platform approximately seven minutes before the end of the performance, and the show was stopped," a statement from the musical said. "All signs were good as he was taken to the hospital for observation."
A police spokesman confirmed that a male actor was injured at about 10:42 p.m. and taken to Bellevue Hospital Center.
One audience member told the Times that the accident happened during a scene when Spider-Man was rescuing his love interest, Mary Jane, while she dangled from a rope attached to a bridge. The witness said he saw the actor playing Spider-Man appear to trip and fall from the bridge into an open pit at the end of the stage.
"You heard screams," he said. "You heard a woman screaming and sobbing."
The actor is the fourth performer to be hurt working on the Julie Taymor-directed musical, which involves many complex aerial stunts.
The production has also been plagued with technical issues and, at $65 million and counting, is the most expensive Broadway show in history. On Friday, the production company confirmed news previously reported by The Hollywood Reporter that it was delaying Spider-Man's official opening night by four weeks to refine creative aspects of the show.