Eric Clapton will be surrounded by esteemed guests at his second Crossroads Guitar Festival, to be held July 28 at Toyota Park in Chicago. B.B. King, Jeff Beck, John Mayer, Sheryl Crow, Willie Nelson and Vince Gill lead the lineup for the event, which follows the inaugural Crossroads in 2004 in Dallas.

The bill will also feature Buddy Guy, Robert Randolph and the Family Band, Steve Winwood, Albert Lee, Derek Trucks, Alison Krauss & Union Station, Derek Trucks, John McLaughlin, Sonny Landreth, the Robert Cray Band, Hubert Sumlin, Doyle Bramhall and Jimmie Vaughan. Tickets go on sale March 31.

The lineup was curated by Clapton and Scooter Weintraub, who is producing the day-long event.

The inaugural Crossroads Guitar Festival in 2004 drew more than 46,000 concertgoers to Dallas’ Cotton Bowl and grossed $2.4 million, according to Billboard Boxscore. The sold-out concert was chronicled in a two-disc DVD.

Proceeds from this year's event will benefit Clapton's Antigua-based rehab facility, the Crossroads Centre.

Clapton is in the midst of a North American tour, which rolls into Seattle tonight (March 22) and wraps April 6 in Columbus, Ohio.