Ke$ha’s “We R Who We R” is set to become just the 17th song (of 992 chart-toppers) to debut at No. 1 on the Billboard Hot 100, when the chart is officially released tomorrow (Nov. 4). The track is the preview single from her forthcoming “Cannibal” album, set to be released on its own on November 22 in addition to being packaged with her debut album “Animal” in a deluxe edition titled “Animal Cannibal.”

"We R Who We R" shifts 280,000 downloads in its initial week at retail, according to Nielsen SoundScan, to easily rank at No. 1 on Digital Songs, knocking Far*East Movement’s “Like a G6” (178,000, down 13%) to No. 2 on both that chart and the Hot 100. “G6” topped the latter list the past two weeks and had led Hot Digital Songs for three non-consecutive frames.

Ke$ha’s track is also making an swift impact at radio, debuting at No. 49 on Hot 100 Airplay (up 81%) and jumping 36-23 on Mainstream Top 40 (up 124%).

“We R Who We R” is the second title this year to start its chart life at No. 1, following Eminem’s “Not Afraid” in May. Prior to Eminem’s debut, Britney Spears had been the last artist to enter at No. 1, with “3” in October 2009.

Ke$ha is no stranger to the top of the Hot 100. Earlier this year she became the 11th solo female to collect at least four Billboard Hot 100 top 10s from a debut album. First single “TiKToK topped the chart for nine weeks starting with the Hot 100 dated Jan. 2, 2010, followed by “Blah Blah Blah” (No. 7), “Take It Off” (No. 8) and “Your Love Is My Drug” (No. 4). In addition to those titles, Ke$ha had a top 10 appearance on 3OH!3’s “My First Kiss” (No. 9) in May.