Though the collaboration seems like a shock to most, they've been pals for quite some time: Manson accompanied Depp to the premiere of "Pirates of the Caribbean: Dead Man's Chest," and a remix version of Manson's track "The Nobodies" was featured in Depp's 2001 film "From Hell."
The two have also dabbled in each other's fields: Manson's most notable film role was in the 1997 David Lynch film "The Lost Highway," and Depp has been playing guitar since adolescence: he currently plays with his band, P, and was invited to play alongside Eddie Vedder last year.
The duo's cover of the 1972 single "You're So Vain" will be featured as a bonus track on Manson's upcoming eighth studio album, "Born Villian," due out May 1 on Manson's personal label, Hell, etc. Records. The album follows 2009's "The High End of Low," which reached No. 4 on the Billboard 200.
Manson will also embark on his first U.S. tour since 2009, kicking off at the Revolver "Golden Gods Awards" on April 11 in Los Angeles. Depp has kept himself busy this year filming "The Lone Ranger" (playing Tonto) which is slated for a 2013 release.