The musician, on the "Watch the Throne" tour in the UK, was not present. A member of his camp reportedly called the LAPD to report the burglary on Wednesday morning.
No "obvious" items were reported missing from the scene of the crime, with investigators waiting for West's presence to establish any stolen possessions.
The three-bedroom Hollywood Hills home is currently on the market for nearly $4 million. According to E! Online, West previously tried to sell the house in 2010.
While West has yet to comment on the incident, his rep did weigh in on inaccurate rumors that he'd tweeted a nude photo of girlfriend Kim Kardashian.
"In regards to this 'story' that Kanye posted and then took down intimate pictures on his Twitter account: TOTALLY FALSE. Laughably so," the rep reportedly told E! Online on Wednesday.
In less unfortunate news, West recently celebrated his 35th birthday and released the video for current single "Mercy."