It will mark the rap icon's first live television performance in more than a decade and comes on the heels of a stellar year for Em, who not only has the best-selling album of 2010 with "Recovery," but is also up for 10 awards (he's won a total of 11 Grammys since breaking onto the scene in 1999).
Dre is also up for album of the year, as a producer on "Recovery."
A new Dr. Dre album, "Detox," is expected out in the spring. It will be his first studio album since 1999.
Previously announced performers for music's biggest night include Arcade Fire, Lady Gaga, Miranda Lambert, Katy Perry, Barbra Streisand, a duet by Gwyneth Paltrow with Cee Lo Green, as well as a tribute to Aretha Franklin performed by Christina Aguilera, Martina McBride, Jennifer Hudson, Yolanda Adams and Florence Welch.