The performer gushed to her fans after being honored with a record-breaking 13 nods, including Video of the Year, Best Pop Video and Best Female Video for "Bad Romance," a clip that is also the second most-watched YouTube video (260 million views) after Justin Bieber's "Baby."
"I'm so honored for all the little monsters and self-professed freaks of the universe, to have more VMA nominations in a single year than any artist in MTV history," said Lady Gaga in a statement. "A long time ago the world told me and my little monsters we would never be heard. Together, we changed the rules.
"God put me on Earth for three reasons," she continued. "To make loud music, gay videos and cause a damn ruckus."
Lady Gaga's mountain of VMA nominations is a remarkable achievement, but it's simply the latest peak in a short career full of historical highs since she first hit radio airwaves in 2008.
Here is a look at some of Lady Gaga's record-breaking Billboard chart achievements.
RA-RA-RA-'REMIX': Nearly everything Lady Gaga touches turns into a chart hit and her latest release, "The Remix," is no exception.
On the Billboard 200 dated Aug. 21, 2010, the album debuted at No. 6, becoming the first remix set to reach the top 10 since the "Hannah Montana 2: Non-Stop Dance Party" album debuted and peaked at No. 7 on the chart dated Feb. 16, 2008.
"The Remix" boasts 10 re-workings of hits, including "Just Dance" and "Poker Face," by the likes of Stuart Price and FrankMusik.
The collection also entered Dance/Electronic Albums at No. 1, granting Lady Gaga a lock on the entire top three, as "The Fame" and the EP "The Fame Monster" placed at Nos. 2 and 3, respectively. Billboard 200 chart manager Keith Caulfield notes that Lady Gaga became the first act to monopolize Nos. 1-3 in the chart's nine-year history.
TOP OF THE POPS: In a little more than a year, Lady Gaga matched a record that Mariah Carey needed 14 years to achieve.
With a 2-1 rise for "Telephone," Lady Gaga - and the track's featured artist, Beyonce - tied the mark for most No. 1s since Billboard's Nielsen BDS-based Pop Songs radio airplay chart launched in 1992. The pair joined Carey, who tallied six toppers between 1993 and 2005. Rihanna has since joined the trio with a resume of six Pop Songs No. 1s.
Most notably, Lady Gaga reached the Pop Songs summit on her first six tries. Prior to "Telephone," she reigned with "Just Dance," featuring Colby O'Donis, "Poker Face," "LoveGame," "Paparazzi" and "Bad Romance."
'FACE' FACTS: When "Poker Face" shuffled 2-1 on the April 11, 2009, Billboard Hot 100, Lady Gaga became the first artist in nearly 10 years to reach the chart's pinnacle with a pair of career-opening chart entries. She first led the Hot 100 for three weeks in January 2009 with "Just Dance."
The last performer to launch with a pair of Hot 100 chart-toppers had been Christina Aguilera, who scored with "Genie in a Bottle" in 1999 and "What a Girl Wants" in and 2000.
The only other solo female artists to achieve the feat in the Hot 100's 52-year archives are Mariah Carey, with "Vision of Love" and "Love Takes Time" in 1990, and Tiffany, with "I Think We're Alone Now" and "Could've Been" in 1987 and 1988, respectively.
DANCE DOMINATION: Lady Gaga's "The Fame" is the longest-running No. 1 in the history of Billboard's Dance/Electronic Albums chart.
During its run, the performer's debut album has spent an unprecedented 79 weeks atop the list. That's more than twice the amount of time in charge as the second-place set, Gnarls Barkley's "St. Elsewhere," which ruled for 39 weeks in 2006-07.
SEVEN PERFECT 10s: When "Alejandro" jumped 11-8 on the Hot 100 dated May 29, 2010, Lady Gaga became the first female artist in more than a decade to launch a career with seven consecutive top 10 radio singles on the survey.
Monica had been the last woman to manage the milestone, banking seven consecutive Hot 100 top 10s in 1995-99.
On Dance/Club Play Songs, "Alejandro" became Lady Gaga's seventh No. 1 of her eight chart appearances. She missed the summit only in her first visit to the list, with the No. 2-peaking "Just Dance."